KPNA1 and infection: Since infection causes a decrease in the levels of nuclear accumulation of IPOA5-transported cargoes such as GFP-Tag NLS by partially relocalizing them to core positive foci, it is also possible that HCV-induced NPCs similarly impair nuclear targeting of specific host factors such as p53 or STAT1, thus interfering with their functions (Germain et al., 2014).