Many proteins, including nucleolin, hnRNP A1, PTBP1, La, Sam68, hnRNP K, hnRNP C1/C2, SRSF3, and TDP2, that are relocalized as a result of infection have known functions in the replication cycle of picornaviruses (Meerovitch et al., 1993; McBride et al., 1996; Waggoner and Sarnow, 1998; Gustin and Sarnow, 2001, 2002; Back et al., 2002; Ricour et al., 2009a; Fitzgerald and Semler, 2011; Virgen-Slane et al., 2012; Fitzgerald et al., 2013). Here, HNRNPK is linked to infection.