PABPC1 and infection: Similarly, cleavage of the nuclear shuttling polyadenylate-binding protein 1 (PABP1), which functions in regulation of mRNA metabolism and is closely associated with RNA and mRNP complexes, has been proposed to be involved in the inhibition of poliovirus translation because expression of PABP1 resistant to poliovirus 3C mediated cleavage during infection increases viral protein synthesis from non-replicating reporter RNAs and reduces viral RNA accumulation, compared to wild type PABP1 expression (Afonina et al., 1998; Bonderoff et al., 2008).