ERVW-1 and viral infectious disease: Neutralizing antibodies can directly block viral infection by binding tightly to the functional Env, mediating entry inhibition, virus aggregation, complement-dependent inactivation, or triggering antibody-dependent cell-mediated cytotoxicity/virus inhibition (ADCC/ADCVI)28, 29, 30, and thus are ideal targets to be elicited by a vaccine.