Patient with NERD would present a history of acute rhinorrhea and nasal congestion usually accompanied by bronchial symptoms (dyspnea), which develop usually within 1–2 h after ingestion of aspirin or other NSAIDs (e.g., naproxen, diclofenac, or ketoprofen) with known COX-1 inhibitory capacity. This evidence concerns the gene PTGS1 and Nasal congestion.