RNASE3 and Increased total eosinophil count: Increased tissue eosinophilia and release of eosinophil cationic protein (ECP) in nasal polyps from NERD patients have been linked to distinctive profile of cytokine expression and upregulation of cytokines related to eosinophil activation and survival (e.g., IL-5, GM-CSF, RANTES, and eotaxin) [16, 24, 25] and is associated with differential expression of remodeling markers [26].