Interestingly, the three PKD isoforms act in a context- and cell-type dependent, similar or opposing manner17, 31: on the one hand, PKD2 gain-of-function in pancreatic cancer promotes invasion and angiogenesis while PKD1 limits these processes31; on the other hand, angiogenesis in the CAM is similarly promoted by the PKD isoforms29. The gene discussed is PKD1; the disease is familial pancreatic carcinoma.