This study aimed to address two primary goals as follows: (a) to investigate the expression of RIPK4 in various stages of CSCC progression and to identify its clinical utility in diagnostic and prognostic significance, particularly in distinguishing HSIL from chronic cervicitis/LSIL; and (b) to determine the oncogenic functions and molecular mechanism of RIPK4 in cervical cancer cell lines. Here, RIPK4 is linked to chronic cervicitis.