ADIPOQ and Insulin resistance: While increased adiponectin levels are associated with reversal of insulin resistance (Yamauchi et al, 2001; Gao et al, 2013) and are thus considered a beneficial effect of TZD administration (Maeda et al, 2001; Hirose et al, 2002; Yang et al, 2002), the data studied here suggest that TZDs increase them far beyond (3–6 fold) normal levels.