FOXM1 and cancer: Recent research also indicates that deregulated FOXM1 overexpression confers genotoxic and other chemotherapeutic agent resistance in cancer.2, 3, 4, 5, 6, 7 There is already good evidence that FOXM1 acts as a mediator of DNA damage response as well as a modulator of genotoxic agent sensitivity.4, 5, 6, 8, 9, 10 Even though deregulated FOXM1 overexpression is considered key to the development of genotoxic agent resistance, the specific mechanisms involved in FOXM1 deregulation remain unknown.