To explore the potential regulation of FOXM1 by OTUB1 in response to genotoxic agents, we investigated the expression of OTUB1 and FOXM1 in the epirubicin-sensitive MCF-7 and epirubicin-resistant MCF-7EpiR breast carcinoma cell lines following epirubicin treatment. This evidence concerns the gene OTUB1 and breast carcinoma.