To explore the mechanisms by which FOXM1 expression is modulated at the posttranslational level as well as the molecules involved, we performed mass spectrometry analysis of protein complexes co-immunoprecipitated with FOXM1 in the breast carcinoma MCF-7 cell line and identified the deubiquitinase OTUB1 as a novel FOXM1-interacting factor. This evidence concerns the gene OTUB1 and breast carcinoma.