In response to DNA-damaging agents, OTUB1 can stabilize and activate p53, leading to the inhibition of cell proliferation and apoptosis.14, 29 However, p53 expression and function is commonly lost during tumourigenesis and thus, the role of OTUB1 in the subsequent breast cancer progression and drug resistance will not be clear-cut.34, 35. The gene discussed is OTUB1; the disease is breast carcinoma.