OTUB1 and neoplasm: There was also significant correlation between OTUB1 and oestrogen receptor (ER)α observed in our cohort (Supplementary Figure S8), consistent with the previous finding that OTUB1 could deubiquitinate and inhibit the degradation of ERα.18 However, there were no significant correlations between OTUB1 and other clinicopathological parameters including progesterone status, histological type, lymph node involvement and tumour stage (Supplementary Figure S8).