Consistent with the emerging oncogenic role of OTUB1 in cancer, the proliferative and clonogenic assays also show that OTUB1 can enhance the proliferative rate and genotoxic agent resistance of breast cancer cells and that FOXM1 is a crucial substrate of OTUB1 in cancer cell proliferation and genotoxic agent resistance. This evidence concerns the gene FOXM1 and breast carcinoma.