OTUB1 and neoplasm: In multivariate analysis, OTUB1 expression became significantly associated with poor survival after being adjusted for the clinicopathological parameters, including ER status, progesterone status, tumour stage, histological type and lymph-node involvement (P=0.033, relative risk=2.859 for overall survival and P=0.013, relative risk=4.048 for disease-specific survival) (Supplementary Figure S11).