ADIPOQ and obesity due to melanocortin 4 receptor deficiency: To our knowledge, ADIPOQ–CG2 is the only site with comparable data being reported by others—and its SAT-methylation levels were inversely related to ADIPOQ expression in females.17 As epigenetic marks display cell specificity, any association between DNA methylation and anthropometric markers might have been influenced by changes in cell composition, for example, obesity-induced macrophage infiltration.