The contribution of epigenetic alterations such as DNA methylation to obesity or obesity-related comorbidities is not completely understood; however, previous studies have linked measures of obesity to differential DNA methylation in blood cells.1, 2 Comparable investigations for adipose tissue (AT) are scarce, although AT is the major fat-storage site and releases bioactive compounds that modulate insulin sensitivity and systemic metabolism.3 The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.