In one family (LCA-6) we were unable to identify the causative gene/mutation in the known LCA candidate gene(s); there were two homozygous blocks with known LCA genes, RPGRIP1 and MERTK. These two did not harbor any pathogenic mutation, however there were fourteen other homozygous blocks shared between the affected and ranging in size from 1-7Mb with no known LCA candidate genes. The gene discussed is RPGRIP1; the disease is Leber congenital amaurosis.