LCA presents with variety of fundus changes e.g. the marbleized fundus appearance in CEP290 gene mutation, RPE atrophy, arteriolar narrowing, pigmentation in fundus in RPE65 gene involvement, granular pigmentation in GUCY2D and peripheral coats like vasculopathy in CRBI mutation etc [4]. Here, RPE65 is linked to Leber congenital amaurosis.