CARD8 and cancer: Thus, the variant genotype GG of rs7248320 in lncRNA AC008392.1 may be associated with activation of NFκB and apoptosis inhibition through down-regulation of CARD8, and consequently promote the development and progression of infection-related cancer, including HCC and cervical cancer, which was consistent with the risk effect of the variant genotype GG of rs7248320 in the results of our study.