Thus, the variant genotype GG of rs7248320 in lncRNA AC008392.1 may be associated with activation of NFκB and apoptosis inhibition through down-regulation of CARD8, and consequently promote the development and progression of infection-related cancer, including HCC and cervical cancer, which was consistent with the risk effect of the variant genotype GG of rs7248320 in the results of our study. Here, NFKB1 is linked to hepatocellular carcinoma.