Leptin signaling-related proteins were commonly expressed in gastric carcinomas except for pSTAT3; pAkt positive in 79% (271/343) of gastric carcinomas, mTOR in 49% (169/33), HIF-1 alpha in 36% (123/343), ERK in 29% (101/343), and pSTAT3 in 8% (29/343). This evidence concerns the gene LEP and gastric carcinoma.