Results from studies on different types of human cancer cells consistently show that RPS induces apoptosis in cancer cells by activating both caspase-dependent and caspase-independent apoptotic pathways and inhibits the migration and invasion by suppressing the enzymatic activity and protein expression of matrix metalloproteinases (MMP) such as MMP-2 and MMP-9 [6–19]. This evidence concerns the gene MMP9 and cancer.