However, the analysis of invariant sites using the gVCF file showed that the patient is also homozygous reference for the risk allele T at site rs10428132, which is located in the gene SCN10A and that, according to GWAS data, is the locus most strongly associated (OR = 2.55; P = 1 x 10-68) with Brugada syndrome, a rare disease with a high risk of sudden cardiac death reflecting uncoordinated electrical activity in the lower chambers of the heart [54]. The gene discussed is SCN10A; the disease is Brugada syndrome.