Although these studies suggest possible links between Glis3, Itch and the physiological functions of Glis3, future studies are needed to further characterize the relationship between Itch-mediated degradation of Glis3 and the generation of pancreatic ß cells and the development Glis3-associated diseases, including type I and type 2 diabetes, osteopenia, and polycystic kidney disease. This evidence concerns the gene GLIS3 and polycystic kidney disease.