HTRA1 and age-related macular degeneration: Further, we have shown that the presence of the G2 allele decreases significantly the expression of myh9. Similar to the common haplotype on 10q26 that influences age-related macular degeneration underscored by complex regulatory events of neighboring genes ARMS2 and HTRA1, our data highlight further the importance of comprehensive evaluation of functional consequences at a susceptibility locus[56].