On the basis of the random effects model, the pooled OR for the T-allele of GNβ3 C825T showed a significant correlation with depression risk under the allele model (C-allele versus T-allele: OR = 1.39, 95% CI = 1.13–1.72, Z = 3.10, P = 0.002; Fig 2). Here, GNB3 is linked to major depressive disorder.