We determined the DROSHA rs10719 CC genotype was associated increased risk of colon cancer in subjects 62 years or older (AOR = 3.875; 95% CI, 1.432–10.490) and patients with HTN (AOR, 3.292; 95% CI, 1.362–7.958), DM (AOR = 6.764; 95% CI, 1.424–32.126) (Table 8). Here, DROSHA is linked to hypertensive disorder.