Although DROSHA rs10719 CC genotype carriers and RAN rs14035 CC heterozygotes showed reduced risk of rectal cancer (Table E in S1 File), we observed no significant association between genotype frequencies for the four miRNA machinery genes and patient survival or TNM classification stage of their malignant CRC tumors (Table F in S1 File and Table G in S1 File). The gene discussed is RAN; the disease is colorectal carcinoma.