In addition, we determined the DROSHA rs10719 CC genotype was associated with increased risk of colon cancer in subjects at 62 years or older (AOR = 3.148; 95% CI, 1.276–7.766; P = 0.013) and subjects younger than 62 years (AOR = 2.940; 95% CI, 1.169–7.399; P = 0.022; Table 6). Here, DROSHA is linked to colonic neoplasm.