In vivo studies of immunostaining of CDH5 have shown that it is highly expressed at EC borders in the abdominal aorta [55], which is a region protected from atherosclerosis with more synchronous hemodynamics (SPA = −45°) [56], but CDH5 staining is markedly reduced in the stenotic region of arteries with stenosis and not detectable downstream of the stenotic region [55]. The gene discussed is CDH5; the disease is atherosclerosis.