NLRP3 and silicosis: Moreover, it was quickly realized that the NLRP3/Caspase-1/IL-1β-cascade was also responsible for the proinflammatory effects of crystalline silica, asbestos, and aluminum salts in macrophages and other phagocytic immune cells [252,253], and NLRP3 was reported to be essential for development of silicosis in mice [252,254].