Moreover, because our previous study has shown that the modulation of T helper cell differentiation affects the pathogenesis of allergic diseases such as atopic dermatitis (AD), which is characterized by the predominant production of Th2 cells [48], the alteration of the Th1/Th2 balance by SRG3 expression may represent a therapeutic strategy to protect against the onset of allergic diseases. Here, SMARCC1 is linked to Alzheimer disease.