For example, colorectal cancers such as colon adenoma, adenocarcinoma, and rectal adenoma showed significant upregulation of CACNA1C when compared to normal control tissues, with p-values ranging from 2.58E-5 to 7.33E-14 and CACNA1C ranking from 2% to 8%. The gene discussed is CACNA1C; the disease is colon adenoma.