PLIN2 and hydrops fetalis: Loss of Bacteroidetes on HF diets was accompanied by significantly increased relative abundances of Firmicutes in both Plin2-null and WT strains (Plin2-null: 39.5% vs. 59.0% RA for chow vs. HF, p = 0.004; WT: 44.3% vs. 54.7% RA, p = 0.009; Fig 4A).