found that the expression of cyclooxygenase-2 (COX-2), prostaglandin E synthetase (PGES), lung-related resistance protein (LRP) and glutathione-S-transferase (GSTs) could rendered the chemo-resistant of A549 NSCLC orthotopic xenografts, and these molecular expression were correlated with NSCLC prognoses 39, thus we speculated that these molecules may also be associated with the radiation resistance of NSCLC, but it was needed experiments to clarify. Here, HPGDS is linked to non-small cell lung carcinoma.