Notably, the 14-3-3 interaction with core components of the mitochondrial apoptotic machinery, including the BCL-2 antagonist of cell death (BAD), BCL-2 interacting mediator of cell death (BIM) and BCL-2-associated X protein (BAX), with proteins that transmit pro-apoptotic signals, including the stress-responsive kinase (ASK1), forkhead box O1 (FOXO1) transcription factor and c-ABL kinase may connect BCR-ABL1 TK signaling pathways to CML phenotype [34–39]. This evidence concerns the gene MAP3K5 and chronic myelogenous leukemia, BCR-ABL1 positive.