Here we showed that CBY1 binding with 14-3-3σ affects CBY1 expression in BCR-ABL1+ cells (both in the C22orf2 K562 cell line, where CBY1 over-expression permits CBY1/14-3-3σ interaction, and in bone marrow cells from CML patients at clinical diagnosis). The gene discussed is CBY1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.