RYR2 and event death: Though the list of genotyped variants is far from being comprehensive, the selected candidate genes are known to be critically involved in the pathomechanisms of sudden cardiac death which encompass dysrhythmias (SCN5A), perturbed intracellular calcium signaling (RYR2 and NOS1AP), myocardial remodeling (TGFBR2) and sympathetic activation (ADRB2).