To estimate the potential of CDK5 as a target for clinical therapy, the effect of CDK5 silencing was further tested in the HEYA8 and A2780 orthotopic mouse models of human ovarian cancer in Nu/Nu mice using the well-characterized DOPC (1,2-dioleoyl-sn-glycero-3-phosphatidylcholine) nanoliposomal delivery system [27, 28]. Here, CDK5 is linked to ovarian carcinoma.