While the percentage of pSTAT3-positive cells in pure ADH was similar to that in tumor-adjacent ADH (p = 0.9, Fig 1D), the pSTAT3-postive cell frequency in either pure ADH or tumor-adjacent ADH was significantly increased compared to that in normal breast epithelia (p = 0.0018 and p = 0.003 respectively, Fig 1D). The gene discussed is AVP; the disease is neoplasm.