Further analysis of excised intestinal polyps showed that the adoptive transfer of Apc HET Tregs reduced the levels of proinflammatory mediators IL-6, IL-1β, and IL-23 in the tumor microenvironment compared with wild type intestinal tissue (Figure 3(d)) but the expression level of TNF was not decreased (Supplementary Figure 3). Here, IL1B is linked to neoplasm.