Recently, a mutation in codon 349 (nucleotide position 1045; c.1045A>G) of the ERAP1 gene was reported in melanoma cell lines [20]; to investigate association of this mutation with protein expression, mutation analysis on DNA from pure tumor cell fractions (obtained by flow sorting) of the 16 ERAP1 downregulated cases was performed. Here, ERAP1 is linked to melanoma.