ERAP1 and cervical carcinoma: Furthermore, genetic variation in the ERAP1 gene has been shown to be significantly associated with risk of developing cervical carcinoma and with prognosis of cervical carcinoma patients [8–10]; specifically, a SNP at the ERAP1-127 locus was shown to be an independent predictor of both cervical carcinoma risk and cervical carcinoma-associated survival, possibly due to its location in the peptidase M1 domain of the ERAP protein [9].