In addition, microRNA-143 and microRNA-145 have been shown by three studies [77–79] to potentially play a role in PC bone metastasis by targeting the EMT regulator HEF1 [79] and the stem cell markers CD133, CD44, Oct-4, c-myc, and Klf4 [78]. The gene discussed is POU5F1; the disease is pachyonychia congenita.