IL17A and primary biliary cholangitis: It has been well described that not only the serum concentrations of IL-17 and IL-17-related cytokines such as IL-23, IL-1β, and IL-6 but also the mRNA expression levels of IL-17-mediated signaling pathway such as IL-23 p19, IL-23R, and IL-17 in PBMCs from PBC patients were significantly elevated compared to the healthy control [57, 58].