Rampersaud et al. [29] investigated the associations of physical activity, common FTO gene variants with BMI, and obesity in Old Order Amish (OOA) individuals, and the results showed that rs1477196 was significantly associated with BMI (P < 0.001), and this effect had significant interaction with physical activity (P = 0.004). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.