To explore the role of FTO polymorphisms in breast cancer development and progress, we performed a case-control study to assess the associations of six cancer-related FTO polymorphisms (rs9939609, rs1477196, rs6499640, rs16953002, rs11075995, and rs1121980) with breast cancer risk and prognosis and BMI levels in healthy controls in Chinese population. The gene discussed is FTO; the disease is breast cancer.