To explore the role of FTO polymorphisms in breast cancer development and progress, we performed a case-control study to assess the associations of six cancer-related FTO polymorphisms (rs9939609, rs1477196, rs6499640, rs16953002, rs11075995, and rs1121980) with breast cancer risk and prognosis and BMI levels in healthy controls in Chinese population. Here, FTO is linked to breast carcinoma.