The OMM kinase, phosphatase and tensin homolog (PTEN)-induced putative kinase protein 1 (PINK1) and the cytosolic E3 ubiquitin ligase Parkin, the mutations of which are causative for hereditary Parkinson's disease, are known to mediate mitophagy to eliminate damaged mitochondria in many types of cells10. The gene discussed is PRKN; the disease is Parkinson disease.