Elevated hDus2 mRNA and protein levels were identified in a range of NSCLC cell lines, and siRNA-dependent knockdown of hDus2 decreased colony formation and cell viability, while hDus2 immuno­histochemical staining correlated with patient survival and was also defined as an independent prognostic factor for the development of NSCLC (Kato et al., 2005 ▸). This evidence concerns the gene DUS2 and non-small cell lung carcinoma.