RHOH and neoplasm: We have generated the tTF-pHLIP fusion protein in which the N-terminus of pHLIP was fused to the C-terminal region of tTF, and found that tTF-pHLIP can localize to the acidic tumor endothelium of blood vessels in tumor-bearing mice and induce local intravascular thrombosis (Figure 1A), resulting in tumor infarction and regression without overt side effects.