IL6 and glioblastoma: Cheng-Yi et al. demonstrated a trend to a difference on OS between patients with IL-6 positive immunohistochemistry (5/11) in GBM patients, 7 months median survival versus 16 months, p = 0.075 [44], whereas in our cohort the median OS for patients with low IL-6 mRNA expression (< median 0.081) was 17 months in relation to those with high IL-6 expression levels (>0.081), that had an median OS of 16 months (p = 0.97).