This SNP has been shown to interfere with an Ets2 binding site in the TERT promoter, and Xu and collaborators (2008) have shown that the minor genetic variant (the C-allele) inhibits c-Myc binding to the E-box consensus site that is present with the major T-variant allele in breast cancer cells [31]. The gene discussed is MYC; the disease is breast carcinoma.