TNFAIP3 and rheumatoid arthritis: Moreover, the genetic alteration of A20 in one patient with both rs2230926 TG genotype and rs146534657 AG genotype and poor outcome appeared to be different from most RA patients because it appeared with rs661561 AA genotype, which was found in almost all of the RA patients and healthy individuals with homozygous (CC genotype) or heterozygous (AC genotype) [30].