Among the 50 RA patients, rs2230926 TG genotype was identified in 3 RA patients, one patient both with rs2230926 TG genotype and rs146534657 AG genotype was poor response to immune suppression therapy, such as methotrexate, infliximab and anti-TNF-α antibody; the second and the third patients both with rs2230926 TG genotype and rs5029937 GT genotype suffered severe disease with systemic joint destruction. Here, TNF is linked to rheumatoid arthritis.