However, the FABP5/CRABP2 ratio does not always predict breast cancer cell response to RA, and RA resistance in the squamous cell carcinoma cell line COLO 16 cannot be overcome by either restoration of CRABP2 expression or an increased CRABP2/FABP5 ratio [29], indicating that other factors are involved. The gene discussed is FABP5; the disease is squamous cell carcinoma.