The discovery that there are at least three proteins involved in RA transport in breast cancer cells (CRABP1, CRABP2 and FABP5 [23–25]), helps to address the molecular mechanism governing RA resistance in ER-negative or triple-negative breast cancer, and provides molecular tools to predict and eventually overcome RA resistance in breast cancer prevention and therapy. The gene discussed is CRABP1; the disease is breast carcinoma.