CRABP2 and breast neoplasm: Thus, our TMA analysis shows that: (i) the clinicopathological associations of CRABP1 and 2 at the protein level are in good agreement with that of the gene profiling data, (ii) CRABP1 is more frequently found in the cytoplasm whereas CRABP2 is more abundant in the nucleus of primary breast tumors, and (iii) clinical outcome and prognostic implications can be attributed to cytoplasmic CRABP1 and nuclear CRABP2, suggesting distinct subcellular functions.