Similarly, reduction in the levels of HSP70, HSP90 and HSP90 client proteins were also observed in the xenografted DLBCL tumors treated with doxycycline (Supplementary Figure 3B), suggesting that doxycycline may inhibit DLBCL cell growth through similar mechanism(s) in vitro and in vivo. The gene discussed is HSP90AB1; the disease is diffuse large B-cell lymphoma.