Notably, doxycycline also inhibited the growth of multiple GCB-DLBCL cell lines (Figure 2A and 2C), which do not rely on NF-κB signaling for growth in vitro [11, 13–15], suggesting that doxycycline affects other pathways in addition to NF-κB signaling. Here, NFKB1 is linked to diffuse large B-cell lymphoma.