UBD and hepatocellular carcinoma: FAT10 is over-expressed in inflammation-associated cancers including hepatocellular carcinoma (HCC) and gastrointestinal cancers (Lee et al., 2003; Lukasiak et al., 2008), non-small cell lung cancer (Heighway et al., 2002) as well as glioma (Yuan et al., 2012).