In light of past work from our laboratory on the role of Tbdn loss in endothelial hyperpermeability in retinopathy (Paradis et al., 2002, 2008; Wall et al., 2004; Gendron et al., 2006, 2010), the work herein provides evidence that Tbdn acts through the c-Src/Cortactin pathway to maintain homeostasis of retinal blood vessels. Here, SRC is linked to retinal disorder.