Collectively these studies demonstrated that genistein reduces IL-8 production in cultured CF bronchial gland cells by increasing cytosolic IκBα protein levels, fluvastatin decreased IL-8 production in whole blood in response to Pseudomonas or Aspergillus antigens, and corilagin binds to NF-κB, thus inhibiting NF-κB/DNA interactions and can decrease CXCL8 gene expression in CF bronchial IB3-1 cells. The gene discussed is CXCL8; the disease is cystic fibrosis.