This SNP is upstream of MAP3K1 (MIM: 600982) and modifies a predicted binding site for estrogen receptor alpha (ER-α),50 consistent with the well-established role of estrogen-mediated signaling in breast cancer progression.51,52 For height, rs11677466 showed the best overlap score (0.026; Figure 6). This evidence concerns the gene MAP3K1 and breast cancer.