PKM and lung adenocarcinoma: Multivariate Cox model analysis (with gene, age, gender, stage and differentiation in the model) indicated that PAICS, PPAT and PKM2 are also independently associated with patient survival in lung adenocarcinomas [HR 1.31 (1.05–1.64, P = 0.02), 1.41 (1.03–1.92, P = 0.03), 1.60 (1.18–2.17, P = 0.002) for PAICS, PPAT or PKM2 respectively].