On the other hand, the antibodies against human CD34 and CD45 antigens did not detect any CD34 and CD45 positive cells circulating in PB of NRG mice without the transplantation of human AML cells, indicating that these antibodies did not have cross-species activity with murine CD34 and CD45 antigens (Fig.1). The gene discussed is PTPRC; the disease is acute myeloid leukemia.