In human adipocytes, the R2 methylation was not only positively correlated with body mass index (Fig. 1g,h) but also negatively associated with adiponectin transcripts (Fig. 1i), findings that further support the potential role of DNA methylation in the R2 to mediate obesity-induced dysregulation of adiponectin expression. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.