TNF and obesity due to melanocortin 4 receptor deficiency: Moreover, RG108 mitigated obesity-induced chronic inflammation in adipose tissues (Fig. 6f–h), whereas the DNA methylation degrees at several promoters of inflammation-related genes such as Pparγ2, Tnfα and Mcp-1 were not altered by RG108 (Supplementary Fig. 7i–n).