In bone-marrow-transplantation models, latent MHV-68 infection leads to chronic and persistent pneumonitis and fibrosis, which is associated with the accumulation of macrophages and the influx of neutrophils and lymphocytes into the lung, with the latter being dominated by CD8 and CD4 T cells (Coomes et al., 2011). This evidence concerns the gene CD8A and pneumonitis.