Epidermal keratinocytes are responsive to dendritic cell-derived and T-cell-derived cytokines such as IFNs, TNF, IL-6, IL-17 and the IL-20 family of cytokines and vice versa, they are able to release proinflammatory cytokines and chemokines to sustain or even amplify the chronic inflammatory disease loop in lesional skin in psoriasis1. The gene discussed is TNF; the disease is neoplasm.