COPS5 and neoplasm: MIF is functionally unique among the cytokines; it acts upon multiple processes that are fundamental to tumorigenesis (e.g., tumor proliferation, evasion of apoptosis, angiogenesis and invasion) by activating the ERK-1/2 and AKT pathways and regulating JAB1, p53, SCF ubiquitin ligases, and HIF-130, 31.