HMGA2 and neoplasm: Immunohistochemical staining of tissue sections revealed that the HMGA2 protein was exclusively expressed in the nucleus of tumor cells and was completely absent in the epithelia of the paired adjacent normal samples (Fig. 4B), whereas MIF was highly expressed in the cytoplasm of tumor cells, but the paired adjacent normal epithelium samples showed little or no expression of MIF (Fig. 4B).