MIF and lip and oral cavity carcinoma: We also found that higher MIF expression in oral cancer cells was associated with many clinicopathological manifestations related to more aggressive tumor properties (e.g., cervical metastasis, perineural invasion, and deeper tumor invasion depth), and that siRNA-mediated silencing of MIF in vitro attenuated the migration and invasion capability in OSCC cells (Table 2 and Fig. 6).