Positive HMGA2 expression was significantly associated with a higher pT status, a higher pN status, a higher overall pathological stage, poorer cell differentiation, positive perineural invasion, and greater tumor depth (P = 0.036, < 0.001, < 0.003, < 0.001, < 0.001, and < 0.001, respectively; Table 2). The gene discussed is HMGA2; the disease is neoplasm.